The Crossing Over


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Event Information

This displaces the original paired strand on the nonsister chromatid, which is then freed to pair with the other single-stranded tail.

The Biology of Crossing-over

The gaps are filled by a DNA polymerase enzyme. Finally, the two chromatids must be separated from each other, which requires cutting all the strands and rejoining the cut ends. A chiasma occurs at least once per chromosome pair. Thus, following crossing over, at least two of the four chromatids become unique, unlike those of the parent. Crossing over can also occur between sister chromatids; however, such events do not lead to genetic variation because the DNA sequences are identical between the chromatids.

Crossing over helps to preserve genetic variability within a species by allowing for virtually limitless combinations of genes in the transmission from parent to off-spring. The frequency of recombination is not uniform throughout the genome. Some areas of some chromosomes have increased rates of recombination hot spots , while others have reduced rates of recombination cold spots.

The frequency of recombination in humans is generally decreased near the centromeric region of chromosomes, and tends to be greater near the telomeric regions.

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Recombination frequencies may vary between sexes. Crossing over is estimated to occur approximately fifty-five times in meiosis in males, and about seventy-five times in meiosis in females. The forty-six chromosomes of the human diploid genome are composed of twenty-two pairs of autosomes, plus the X and Y chromosomes that determine sex. The X and Y chromosomes are very different from each other in their genetic composition but nonetheless pair up and even cross over during meiosis.

These two chromosomes do have similar sequences over a small portion of their length, termed the pseudoautosomal region, at the far end of the short arm on each one. The pseudoautosomal region behaves similarly to the autosomes during meiosis, allowing for segregation of the sex chromosomes.

Just proximal to the pseudoautosomal region on the Y chromosome is the SRY gene sex-determining region of the Y chromosome , which is critical for the normal development of male reproductive organs. When crossing over extends past the boundary of the pseudoautosomal region and includes this gene, sexual development will most likely be adversely affected.

Crossing Over and Recombination

The rare occurrences of chromosomally XX males and XY females are due to such aberrant crossing over, in which the Y chromosome has lost — and the X chromosome has gained — this sex-determining gene. Most crossing over is equal. However, unequal crossing over can and does occur. This form of recombination involves crossing over between nonallelic sequences on nonsister chromatids in a pair of homologues. In many cases, the DNA sequences located near the crossover event show substantial sequence similarity.

When unequal crossing over occurs, the event leads to a deletion on one of the participating chromatids and an insertion on the other, which can lead to genetic disease, or even failure of development if a crucial gene is missing. Recombination events have important uses in experimental and medical genetics.

They can be used to order and determine distances between loci chromosome positions by genetic mapping techniques. Loci that are on the same chromosome are all physically linked to one another, but they can be separated by crossing over. Examining the frequency with which two loci are separated allows a calculation of their distance: The closer they are, the more likely they are to remain together.

Multiple comparisons of crossing over among multiple loci allows these loci to be mapped, or placed in relative position to one another. Recombination frequency in one region of the genome will be influenced by other, nearby recombination events, and these differences can complicate genetic mapping. The term "interference" describes this phenomenon. In positive interference, the presence of one crossover in a region decreases the probability that another crossover will occur nearby.

Negative interference, the opposite of positive interference, implies that the formation of a second crossover in a region is made more likely by the presence of a first crossover.

Most documented interference has been positive, but some reports of negative interference exist in experimental organisms. The investigation of interference is important because accurate modeling of interference will provide better estimates of true genetic map length and intermarker distances, and more accurate mapping of trait loci. Interference is very difficult to measure in humans, because exceedingly large sample sizes, usually on the order of three hundred to one thousand fully informative meiotic events, are required to detect it.

Highlights

Strachan, Tom, and Andrew P. Human Molecular Genetics. New York : Wiley-Liss, Cite this article Pick a style below, and copy the text for your bibliography. Speer, Marcy C. November 1, Retrieved November 01, from Encyclopedia. Then, copy and paste the text into your bibliography or works cited list. Because each style has its own formatting nuances that evolve over time and not all information is available for every reference entry or article, Encyclopedia.

Crossing over occurs in the first division of meiosis. At that stage each chromosome has replicated into two strands called sister chromatids. The two homologous chromosomes of a pair synapse, or come together. While the chromosomes are synapsed, breaks occur at corresponding points in two of the non-sister chromatids, i. Since the chromosomes are homologous, breaks at corresponding points mean that the segments that are broken off contain corresponding genes , i.

The broken sections are then exchanged between the chromosomes to form complete new units, and each new recombined chromosome of the pair can go to a different daughter sex cell.

Energy Flow 3. Carbon Cycling 4. Climate Change 5: Evolution 1.

Crossing Over () - IMDb

Evolution Evidence 2. Natural Selection 3. Classification 4. Cladistics 6: Human Physiology 1. Digestion 2. The Blood System 3. Disease Defences 4.

Crossing-Over and Chromosome Disjunction

Gas Exchange 5. Homeostasis Higher Level 7: Nucleic Acids 1. DNA Structure 2. Transcription 3. Translation 8: Metabolism 1. Metabolism 2. Cell Respiration 3. Photosynthesis 9: Plant Biology 1. Xylem Transport 2. Phloem Transport 3. Plant Growth 4.

crossing over

Plant Reproduction Genetics 1. Meiosis 2. Inheritance 3. Speciation Animal Physiology 1. Antibody Production 2.

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